Frane graduated in Veterinary Medicine from the Vetsuisse Faculty of the University of Zurich, Switzerland, in 2015. In 2017, he started a rotational internship with a focus on cardiology, which led him to the ECVIM-CA specialisation programme (cardiology) in 2018, which he successfully completed in 2022.

Frane then started working as a freelance cardiologist in several centres in Switzerland, offering on-site consultations in the French, German and Italian speaking regions through his company 'VetMeister'. In April 2022, he worked for six months at the University of Zurich in the Department of Endocrinology, while continuing to develop his freelance activity.

From January 2023, Frane re-established the Cardiology Service at the University of Glasgow, taking over as Head of Service and participating in various areas of comparative research with the aim of further developing the range of services offered.